Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9649751 | 0.85 | TSHR (0.42) | CYP2C19CYP3A4KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3494517 | 0.78 | CLCN2 (0.40) | CLCN2KMT2AMEN1FOLH1POLB | |
| SCHEMBL9356364 | 0.76 | CYP2C19 (0.55) | CYP2C19MAPTCYP3A4KMT2AMEN1 | |
| SCHEMBL8114342 | 0.75 | CLCN2 (0.42) | CLCN2KMT2AMEN1FOLH1POLB | |
| SCHEMBL12985387 | 0.74 | ALDH1A1 (0.41) | CLCN2MAPTCYP3A4KMT2AMEN1 | |
| SCHEMBL10276952 | 0.74 | CLCN2 (0.43) | CLCN2KMT2AMEN1POLBHTT | |
| SCHEMBL10952808 | 0.73 | CYP2C19 (0.60) | CYP2C19KMT2AMEN1SMN1; SMN2POLB | |
| SCHEMBL7717929 | 0.72 | FOLH1 (0.58) | CYP2C19KMT2AFOLH1PPARGPPARA | |
| SCHEMBL822012 | 0.72 | CYP2C19 (0.39) | CYP2C19MAPTCYP3A4KMT2AMEN1 | |
| SCHEMBL9647401 | 0.72 | TDP1 (0.45) | CYP3A4KMT2AMEN1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166377-A | Thromboxane A2 antagonist as coagulants or vasoconstrictors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-11-24 | — | — | US | disclosed |
| US-4745198-A | CARDIOVASCULAR DISORDERS, BRONCHODILATOR AGENTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-05-17 | — | — | US | disclosed |
| EP-0094239-B1 | 1,3-DIOXAN-5-YLALKENOIC ACIDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-07-15 | — | — | EP | disclosed |
| US-4567197-A | THORMBOXANE A2 ANTAGONISTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-01-28 | — | — | US | disclosed |
| EP-0094239-A2 | 1,3-Dioxan-5-ylalkenoic acids | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-11-16 | — | — | EP | disclosed |