Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9647401 | 0.87 | TDP1 (0.45) | TSHRTDP1CYP3A4L3MBTL1MEN1 | |
| SCHEMBL9650318 | 0.85 | CYP2C19 (0.46) | CYP3A4MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9650272 | 0.85 | LMNA (0.44) | TSHRTDP1CYP3A4MEN1KMT2A | |
| SCHEMBL9649781 | 0.85 | KDM4E (0.44) | TSHRTDP1CYP3A4MEN1KMT2A | |
| SCHEMBL9650914 | 0.84 | KMT2A (0.46) | TSHRTDP1L3MBTL1MAPK1MEN1 | |
| SCHEMBL9647521 | 0.82 | KCNK3 (0.39) | TSHRTDP1CYP3A4MAPK1MEN1 | |
| SCHEMBL9647321 | 0.81 | MEN1 (0.49) | TDP1MAPK1MEN1KMT2ANPC1 | |
| SCHEMBL9715146 | 0.77 | L3MBTL1 (0.37) | TSHRTDP1L3MBTL1MAPK1KMT2A | |
| SCHEMBL1825614 | 0.76 | LMNA (0.43) | L3MBTL1MAPK1MEN1KMT2AMMP8 | |
| SCHEMBL286 | 0.75 | SLC6A3 (0.51) | TSHRTDP1L3MBTL1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166377-A | Thromboxane A2 antagonist as coagulants or vasoconstrictors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-11-24 | — | — | US | disclosed |
| US-4745198-A | CARDIOVASCULAR DISORDERS, BRONCHODILATOR AGENTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-05-17 | — | — | US | disclosed |
| EP-0094239-B1 | 1,3-DIOXAN-5-YLALKENOIC ACIDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-07-15 | — | — | EP | disclosed |
| US-4567197-A | THORMBOXANE A2 ANTAGONISTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-01-28 | — | — | US | disclosed |
| EP-0094239-A2 | 1,3-Dioxan-5-ylalkenoic acids | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-11-16 | — | — | EP | disclosed |