Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 2/20 | 0.32 |
| ▸ | GABRD | O14764 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9650518 | 0.80 | HTR2C (0.37) | CHRNB4CHRNA3ALDH1A1NPY5RRAB9A | |
| SCHEMBL16579554 | 0.71 | NPC1 (0.30) | RAB9ANPC1 | |
| SCHEMBL29546450 | 0.66 | ALDH1A1 (0.52) | CHRNB4CHRNA3ALDH1A1BIRC5RAB9A | |
| SCHEMBL312091 | 0.66 | ALDH1A1 (0.52) | CHRNB4CHRNA3ALDH1A1BIRC5RAB9A | |
| SCHEMBL191276 | 0.64 | ALDH1A1 (0.50) | CHRNB4CHRNA3ALDH1A1BIRC5RAB9A | |
| SCHEMBL26301211 | 0.64 | ALDH1A1 (0.50) | CHRNB4CHRNA3ALDH1A1BIRC5RAB9A | |
| Water SCHEMBL28248751 | 0.64 | ALDH1A1 (0.50) | CHRNB4CHRNA3ALDH1A1BIRC5RAB9A | |
| SCHEMBL15624388 | 0.64 | ALDH1A1 (0.50) | CHRNB4CHRNA3ALDH1A1BIRC5RAB9A | |
| SCHEMBL29398919 | 0.64 | ALDH1A1 (0.50) | CHRNB4CHRNA3ALDH1A1BIRC5RAB9A | |
| SCHEMBL9292507 | 0.64 | TAAR1 (0.54) | BIRC5NPY5RRAB9ANPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5120848-A | Anticholesterol and antilipemic agents; hydroxy-3-methylglutaryl/3-/ coenzyme A reductase inhibitors | GLAXO GROUP LIMITED (GB) | 1992-06-09 | — | — | US | disclosed |
| US-5013749-A | Imidazole derivatives and their use as hypercholesterolemia and hyperlipoproteinemia agents | GLAXO GROUP LIMITED (GB) | 1991-05-07 | — | — | US | disclosed |