SCHEMBL16579554

SCHEMBL16579554

FC1=CC[CH]C(c2ccc(F)cc2)=C1

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9650411 0.84 ACHE (0.34)
SCHEMBL9648522 0.72 TSHR (0.31)
SCHEMBL9650425 0.71 CHRNB4 (0.35) NPC1RAB9A
SCHEMBL17135804 0.62 ACHE (0.37) NPC1RAB9A
SCHEMBL197346 0.61 BCL2L1 (0.55) NPC1RAB9A
SCHEMBL10300262 0.61 BCL2L1 (0.55) NPC1RAB9A
SCHEMBL10337645 0.61 BCL2L1 (0.55) NPC1RAB9A
SCHEMBL12562793 0.61 BCL2L1 (0.55) NPC1RAB9A
SCHEMBL4599704 0.61
SCHEMBL2546251 0.61

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9422282-B2 Compounds and method for treatment of HIV CRITICAL OUTCOME TECHNOLOGIES INC. (CA) 2016-08-23 US disclosed
US-20150183782-A1 COMPOUNDS AND METHOD FOR TREATMENT OF HIV MORGAN STANLEY SENIOR FUNDING, INC. 2015-07-02 US disclosed
US-8987272-B2 Compounds and method for treatment of HIV CRITICAL OUTCOME TECHNOLOGIES INC. (CA) 2015-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150183782-A1 COMPOUNDS AND METHOD FOR TREATMENT OF HIV NNT, CCR5, XDH NPC1 21/4885RAB9A 3745/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.