Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HMGCR | P04035 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17577640 | 0.98 | FDPS (0.36) | FDPSTSHRHMGCRPOLBTP53 | |
| SCHEMBL15981052 | 0.92 | TSHR (0.37) | FDPSTSHRHMGCRPOLBTP53 | |
| SCHEMBL17576905 | 0.87 | FDPS (0.32) | FDPSTSHRHMGCRPOLB | |
| SCHEMBL17576893 | 0.81 | HMGCR (0.33) | FDPSTSHRHMGCRPOLBTP53 | |
| SCHEMBL13334729 | 0.79 | FDPS (0.52) | FDPSTSHRHMGCRPOLBTP53 | |
| SCHEMBL1863534 | 0.79 | POLB (0.39) | TSHRPOLBTP53TDP1 | |
| SCHEMBL23012612 | 0.78 | HMGCR (0.37) | FDPSHMGCR | |
| SCHEMBL2539471 | 0.78 | FDPS (0.36) | FDPSTSHRHMGCRPOLBTP53 | |
| SCHEMBL8602788 | 0.78 | CPB2 (0.39) | FDPSTSHRHMGCRPOLBTP53 | |
| SCHEMBL1851676 | 0.78 | PPARD (0.42) | FDPSTSHRHMGCRPOLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0339237-B1 | PHENOL SUBSTITUTED GEM-DIPHOSPHONATE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYMPHAR S.A. (CH) | 1992-12-30 | — | — | EP | disclosed |
| US-5128331-A | Gen-diphosphonates | SYMPHAR S.A. (CH) | 1992-07-07 | — | — | US | disclosed |
| US-5043330-A | Antiinflammatory and hypotensive agents; antihyperlipemia | SYMPHAR S.A. (CH) | 1991-08-27 | — | — | US | disclosed |
| EP-0339237-A2 | Phenol substituted gem-diphosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR S.A. (CH) | 1989-11-02 | — | — | EP | disclosed |