Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAPK1 | P53355 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | PI4KA | P42356 | 1/20 | 0.43 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.43 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | FDPS | P14324 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | AGER | Q15109 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4096596 | 0.86 | ADORA2A (0.58) | DAPK1ADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL10496728 | 0.82 | DAPK1 (0.49) | DAPK1ADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL9592643 | 0.80 | FGFR1 (0.40) | DAPK1HDAC6FDPSFGFR1FGFR4 | |
| SCHEMBL10579865 | 0.79 | DAPK1 (0.46) | DAPK1ADORA2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL30984022 | 0.76 | ADORA2A (0.70) | DAPK1ADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL2980291 | 0.76 | ADORA2A (0.70) | DAPK1ADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL4094994 | 0.76 | ADORA2A (0.56) | DAPK1ADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL9575530 | 0.74 | ACHE (0.43) | ADORA2AHDAC6 | |
| SCHEMBL5459069 | 0.74 | DAPK1 (0.67) | DAPK1ADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL9417129 | 0.73 | DAPK1 (0.33) | DAPK1HDAC6FDPSFGFR1FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157120-A | Guanine derivatives | SYNTEX (U.S.A.) INC. (US) | 1992-10-20 | — | — | US | disclosed |
| US-4868187-A | Anti-viral N-substituted pyrimidines | SYNTEX (U.S.A.) INC. (US) | 1989-09-19 | — | — | US | disclosed |
| EP-0260596-A2 | 2-Amino-6-alkoxy-purins substituted in position 9, process for their preparation, their use and pharmaceutical compositions containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-03-23 | — | — | EP | disclosed |
| US-4347360-A | Ring open nucleoside analogues | ENS BIO LOGICALS INC. (CA) | 1982-08-31 | — | — | US | disclosed |
| EP-0049072-A1 | Guanine compounds and their use for the preparation of anti-viral agents | SYNTEX (U.S.A.) INC. (US) | 1982-04-07 | — | — | EP | disclosed |