Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8120764 | 0.89 | HPGD (0.42) | HPGDLMNAADRB3AURKAKDR | |
| SCHEMBL8120763 | 0.87 | HPGD (0.41) | HPGDLMNAADRB3AURKAKDR | |
| SCHEMBL8867750 | 0.87 | ALDH1A1 (0.54) | HPGDALDH1A1SMN1; SMN2MEN1CYP2D6 | |
| SCHEMBL8867745 | 0.87 | ALDH1A1 (0.54) | HPGDALDH1A1SMN1; SMN2MEN1CYP2D6 | |
| SCHEMBL11466281 | 0.87 | ALDH1A1 (0.54) | HPGDALDH1A1SMN1; SMN2MEN1CYP2D6 | |
| SCHEMBL11572373 | 0.83 | HPGD (0.43) | HPGDLMNAKCNA5ADRB3AURKA | |
| SCHEMBL22220775 | 0.79 | CA2 (0.47) | HPGDLMNAADRB3AURKAKDR | |
| SCHEMBL9005760 | 0.78 | BRD4 (0.40) | HPGDLMNAADRB3AURKAKDR | |
| SCHEMBL10403342 | 0.77 | BRD4 (0.40) | HPGDLMNAADRB3AURKAKDR | |
| SCHEMBL10403343 | 0.77 | BRD4 (0.42) | HPGDLMNAADRB3AURKAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266896-B1 | 7-( (META-SUBSTITUTED) PHENYLGLYCINE) 1-CARBA-1-DETHIACEPHALOSPORINS | ELI LILLY AND COMPANY (US) | 1992-08-05 | — | — | EP | disclosed |
| EP-0266896-A1 | 7-( (Meta-substituted) phenylglycine) 1-carba-1-dethiacephalosporins | ELI LILLY AND COMPANY (US) | 1988-05-11 | — | — | EP | disclosed |