Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15291280 | 0.87 | CYP3A4 (0.39) | CYP3A4ALOX15HIF1AHSD17B10TSHR | |
| SCHEMBL28855964 | 0.79 | APP (0.46) | ALOX15HSD17B10TDP1LCKALOX5 | |
| SCHEMBL9360230 | 0.78 | MCL1 (0.48) | CYP3A4ALOX15HIF1AHSD17B10TSHR | |
| SCHEMBL1818017 | 0.77 | CYP1A2 (0.50) | CYP3A4HSD17B10TDP1ALOX5CYP1A2 | |
| SCHEMBL24474139 | 0.73 | KDM4E (0.42) | CYP3A4ALOX15HIF1AHSD17B10TSHR | |
| SCHEMBL9361475 | 0.73 | EPHX1 (0.43) | CYP3A4ALOX15HIF1AHSD17B10TSHR | |
| SCHEMBL9361517 | 0.73 | SLC6A4 (0.40) | CYP3A4ALOX15HIF1AHSD17B10TSHR | |
| SCHEMBL9365248 | 0.72 | CA2 (0.46) | CYP3A4ALOX15HIF1AHSD17B10TSHR | |
| SCHEMBL8312829 | 0.71 | CYP1A2 (0.64) | ALOX15HSD17B10TDP1CYP1A2KDM4E | |
| SCHEMBL31255814 | 0.71 | LCK (0.43) | CYP3A4ALOX15HIF1AHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0168277-B2 | POLY(ORTHOESTER)POLYMERS CONTAINING PENDANT ACID FUNCTIONALITIES AND LABILE BACKBONE BONDS | Merck & Co., Inc. (US) | 1992-12-30 | — | — | EP | claimed |
| EP-0168277-B1 | Poly(orthoester)polymers containing pendant acid functionalities and labile backbone bonds | MERCK & CO. INC. (US) | 1990-08-01 | — | — | EP | claimed |
| US-4765973-A | Polymers containing pendant acid functionalities and labile backbone bonds | MERCK & CO., INC. (US) | 1988-08-23 | — | — | US | claimed |
| EP-0168277-A1 | Poly(orthoester)polymers containing pendant acid functionalities and labile backbone bonds | MERCK & CO. INC. (US) | 1986-01-15 | — | — | EP | claimed |
| EP-0168277-B2 | POLY(ORTHOESTER)POLYMERS CONTAINING PENDANT ACID FUNCTIONALITIES AND LABILE BACKBONE BONDS | Merck & Co., Inc. (US) | 1992-12-30 | — | — | EP | disclosed |
| EP-0168277-B1 | Poly(orthoester)polymers containing pendant acid functionalities and labile backbone bonds | MERCK & CO. INC. (US) | 1990-08-01 | — | — | EP | disclosed |
| US-4765973-A | Polymers containing pendant acid functionalities and labile backbone bonds | MERCK & CO., INC. (US) | 1988-08-23 | — | — | US | disclosed |
| US-4639366-A | Polymers containing pendant acid functionalities and labile backbone bonds | MERCK & CO., INC. (US) | 1987-01-27 | — | — | US | disclosed |
| EP-0168277-A1 | Poly(orthoester)polymers containing pendant acid functionalities and labile backbone bonds | MERCK & CO. INC. (US) | 1986-01-15 | — | — | EP | disclosed |