SCHEMBL9654099

SCHEMBL9654099

CN(C(=O)NC(=O)c1c(F)cccc1F)c1ccc(Oc2ncc(C(F)(F)F)cc2Cl)c(Cl)c1F

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LIPE Q05469 1/20 0.47
LMNA P02545 4/20 0.44
HPGD P15428 1/20 0.43
SMN1; SMN2 Q16637 6/20 0.43
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C19 P33261 1/20 0.42
RAB9A P51151 1/20 0.42
TLR8 Q9NR97 1/20 0.41
KMT2A Q03164 3/20 0.41
TLR7 Q9NYK1 1/20 0.41
ATM Q13315 1/20 0.41
POLB P06746 1/20 0.39
GAA P10253 1/20 0.39
ALDH1A1 P00352 3/20 0.39
HTT P42858 2/20 0.39
MEN1 O00255 2/20 0.39
MAPT P10636 2/20 0.39
NPSR1 Q6W5P4 2/20 0.39
XBP1 P17861 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9653559 0.94 LIPE (0.48) LIPELMNAHPGDSMN1; SMN2CYP1A2
SCHEMBL9653604 0.88 TLR7 (0.43) TLR8TLR7FFAR1
SCHEMBL9651074 0.86 LIPE (0.47) LIPELMNAHPGDSMN1; SMN2CYP1A2
SCHEMBL9652559 0.86 LIPE (0.51) LIPELMNAHPGDSMN1; SMN2CYP1A2
SCHEMBL9653579 0.86 LIPE (0.51) LIPELMNAHPGDSMN1; SMN2CYP1A2
SCHEMBL9654165 0.85 LIPE (0.53) LIPELMNAHPGDSMN1; SMN2RAB9A
SCHEMBL9651084 0.83 LIPE (0.52) LIPELMNAHPGDSMN1; SMN2CYP1A2
SCHEMBL9652306 0.81 TLR7 (0.43) TLR8TLR7FFAR1
SCHEMBL10621992 0.80 LIPE (0.50) LIPELMNAHPGDSMN1; SMN2CYP1A2
SCHEMBL10723806 0.78 KMT2A (0.48) LIPELMNAHPGDSMN1; SMN2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0263438-B1 BENZOYLUREA COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND PESTICIDES CONTAINING THEM ISHIHARA SANGYO KAISHA, LTD. (JP) 1992-07-15 EP claimed
US-4985449-A N-benzoyl-N-pyridyloxy phenyl urea compounds and pesticide compositions containing them ISHIHARA SANGYO KAISHA LTD. (JP) 1991-01-15 US claimed
EP-0263438-A2 Benzoylurea compounds, process for their production and pesticides containing them ISHIHARA SANGYO KAISHA, LTD. (JP) 1988-04-13 EP claimed
EP-0263438-B1 BENZOYLUREA COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND PESTICIDES CONTAINING THEM ISHIHARA SANGYO KAISHA, LTD. (JP) 1992-07-15 EP disclosed
US-4985449-A N-benzoyl-N-pyridyloxy phenyl urea compounds and pesticide compositions containing them ISHIHARA SANGYO KAISHA LTD. (JP) 1991-01-15 US disclosed
US-4861799-A INSSECTICIDES ISHIHARA SANGYO KAISHA LTD. (JP) 1989-08-29 US disclosed
EP-0263438-A2 Benzoylurea compounds, process for their production and pesticides containing them ISHIHARA SANGYO KAISHA, LTD. (JP) 1988-04-13 EP disclosed