SCHEMBL9653604

SCHEMBL9653604

CN(C(=O)NC(=O)c1c(F)cccc1F)c1ccc(Oc2ccc(C(F)(F)F)cc2Cl)c(Cl)c1F

nearest known ligand 0.43

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 4/20 0.43
TLR8 Q9NR97 4/20 0.41
MRGPRX4 Q96LA9 9/20 0.41
IL2 P60568 1/20 0.41
CCR1 P32246 1/20 0.40
CCR2 P41597 1/20 0.40
FFAR1 O14842 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9652306 0.94 TLR7 (0.43) TLR7TLR8MRGPRX4IL2CCR1
SCHEMBL9654099 0.88 LIPE (0.47) TLR7TLR8FFAR1
SCHEMBL9653141 0.87 TLR7 (0.50) TLR7TLR8MRGPRX4IL2CCR1
SCHEMBL9651062 0.85 TLR7 (0.48) TLR7TLR8MRGPRX4IL2CCR1
SCHEMBL9653077 0.84 TLR7 (0.56) TLR7TLR8MRGPRX4IL2FFAR1
SCHEMBL9651027 0.83 TLR7 (0.47) TLR7TLR8MRGPRX4IL2CCR1
SCHEMBL9654205 0.83 TLR7 (0.46) TLR7TLR8MRGPRX4IL2CCR1
SCHEMBL9653559 0.81 LIPE (0.48) TLR7TLR8
SCHEMBL4908707 0.80 IL2 (0.44) TLR7TLR8IL2
SCHEMBL9653579 0.76 LIPE (0.51) TLR7TLR8FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0263438-B1 BENZOYLUREA COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND PESTICIDES CONTAINING THEM ISHIHARA SANGYO KAISHA, LTD. (JP) 1992-07-15 EP claimed
US-4861799-A INSSECTICIDES ISHIHARA SANGYO KAISHA LTD. (JP) 1989-08-29 US claimed
EP-0263438-A2 Benzoylurea compounds, process for their production and pesticides containing them ISHIHARA SANGYO KAISHA, LTD. (JP) 1988-04-13 EP claimed
EP-0263438-B1 BENZOYLUREA COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND PESTICIDES CONTAINING THEM ISHIHARA SANGYO KAISHA, LTD. (JP) 1992-07-15 EP disclosed
US-4985449-A N-benzoyl-N-pyridyloxy phenyl urea compounds and pesticide compositions containing them ISHIHARA SANGYO KAISHA LTD. (JP) 1991-01-15 US disclosed
US-4861799-A INSSECTICIDES ISHIHARA SANGYO KAISHA LTD. (JP) 1989-08-29 US disclosed
EP-0263438-A2 Benzoylurea compounds, process for their production and pesticides containing them ISHIHARA SANGYO KAISHA, LTD. (JP) 1988-04-13 EP disclosed