Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 19/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.71 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9662085 | 0.97 | PTAFR (0.72) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL8928418 | 0.94 | PTAFR (0.77) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| Pyrrole SCHEMBL9661972 | 0.90 | PTAFR (0.72) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL10471373 | 0.89 | OPRK1 (0.75) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL10508820 | 0.89 | OPRK1 (0.67) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL10469753 | 0.88 | OPRK1 (0.74) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL9667874 | 0.88 | OPRK1 (0.74) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL10471499 | 0.88 | OPRK1 (0.74) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL9654335 | 0.88 | OPRK1 (0.76) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL9669372 | 0.88 | OPRK1 (0.76) | PTAFRCYP3A4ALOX15OPRK1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155103-A | Methods of using new thieno-triazole-1,4-diazepino-2-carboxylic acid amides | BOEHRINGER INGELHEIM GMBH (DE) | 1992-10-13 | — | — | US | disclosed |
| US-5116971-A | Platelt-activating-factor antagonist | BOEHRINGER INGELHEIM KG (DE) | 1992-05-26 | — | — | US | disclosed |
| US-5082839-A | Platelet activating factor antagonist | BOEHRINGER INGELHEIM GMBH (DE) | 1992-01-21 | — | — | US | disclosed |
| US-4968794-A | ANTAGONISTS OF PLATELET ACTIVATING FACTOR | BOEHRINGER INGELHEIM KG (DE) | 1990-11-06 | — | — | US | disclosed |
| EP-0194416-B1 | THIENO-TRIAZOLO-1,4-DIAZEPINO-2-CARBOXAMIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM KG (DE) | 1989-04-26 | — | — | EP | disclosed |