Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9654914 | 0.87 | ABCB11 (0.59) | ALDH1A1KMT2AHSD17B10L3MBTL1MEN1 | |
| SCHEMBL9658198 | 0.85 | ALDH1A1 (0.47) | ALDH1A1CYP1A2KMT2AHSD17B10MAPK1 | |
| SCHEMBL9657969 | 0.84 | MRGPRX4 (0.45) | ALDH1A1KMT2AHSD17B10MEN1HTT | |
| SCHEMBL9656962 | 0.83 | MEN1 (0.45) | ALDH1A1KMT2AHSD17B10MEN1HTT | |
| SCHEMBL9659120 | 0.83 | SMN1; SMN2 (0.46) | ALDH1A1KMT2AHSD17B10MAPK1L3MBTL1 | |
| SCHEMBL9657956 | 0.83 | KMT2A (0.47) | ALDH1A1KMT2AHSD17B10MAPK1L3MBTL1 | |
| SCHEMBL9657879 | 0.82 | KDM4E (0.50) | ALDH1A1KDM4ECYP1A2CYP2C9IDO1 | |
| SCHEMBL9656608 | 0.79 | KDM4E (0.47) | ALDH1A1KDM4ECYP1A2CYP2C9IDO1 | |
| SCHEMBL30929673 | 0.79 | ALDH1A1 (0.55) | ALDH1A1KMT2AHSD17B10MAPK1L3MBTL1 | |
| SCHEMBL9656750 | 0.78 | KDM4E (0.61) | ALDH1A1KDM4ECYP1A2CYP2C9IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134161-A | Enzyme inhibitors for skin disorders, antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-4786652-A | TOPICAL ADMINISTRATION | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |