Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9654801 | 1.00 | GPR183 (0.62) | GPR183CYP1A2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL16599255 | 0.84 | GPR183 (0.63) | GPR183CYP1A2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL19385657 | 0.84 | GPR183 (0.67) | GPR183CYP1A2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL16599253 | 0.84 | GPR183 (0.63) | GPR183CYP1A2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL1615026 | 0.84 | GPR183 (0.63) | GPR183CYP1A2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL19385656 | 0.84 | GPR183 (0.67) | GPR183CYP1A2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL1615028 | 0.84 | GPR183 (0.63) | GPR183CYP1A2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL9654402 | 0.83 | RAB9A (0.75) | GPR183CYP1A2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL16599161 | 0.83 | GPR183 (0.65) | GPR183CYP1A2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL16599159 | 0.83 | GPR183 (0.65) | GPR183CYP1A2ALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4824842-A | Cinnamoyl piperidines and thiomorpholine and cerebral protection compositions | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1989-04-25 | — | — | US | claimed |
| EP-0192431-A2 | Agent for cerebral protection | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1986-08-27 | — | — | EP | claimed |
| EP-0192431-B1 | AGENT FOR CEREBRAL PROTECTION | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1992-12-16 | — | — | EP | disclosed |
| US-4962107-A | IMPROVED SIDE EFFECT REDUCTION | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1990-10-09 | — | — | US | disclosed |
| US-4824842-A | Cinnamoyl piperidines and thiomorpholine and cerebral protection compositions | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0192431-A2 | Agent for cerebral protection | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1986-08-27 | — | — | EP | disclosed |