Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 3/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1615026 | 1.00 | GPR183 (0.63) | GPR183CYP1A2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL9652217 | 0.86 | GPR183 (0.60) | GPR183CYP1A2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL9652223 | 0.86 | GPR183 (0.60) | GPR183CYP1A2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL19385656 | 0.85 | GPR183 (0.67) | GPR183CYP1A2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL19385657 | 0.85 | GPR183 (0.67) | GPR183CYP1A2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL16599253 | 0.85 | GPR183 (0.63) | GPR183CYP1A2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL16599255 | 0.85 | GPR183 (0.63) | GPR183CYP1A2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL9654792 | 0.84 | GPR183 (0.62) | GPR183CYP1A2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL16599161 | 0.84 | GPR183 (0.65) | GPR183CYP1A2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL9654409 | 0.84 | RAB9A (0.75) | GPR183CYP1A2ALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703957-B2 | Phosphonic acid compounds as inhibitors of serine proteases | JANSSEN PHARMACEUTICA NV (BE) | 2014-04-22 | — | — | US | disclosed |
| US-8304430-B2 | Phosphonic acid compounds as inhibitors of serine proteases | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2012-11-06 | — | — | US | disclosed |
| EP-1620446-B1 | PIPERAZINE CONTAINING PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES | ORTHO MCNEIL PHARMACEUTICAL CORP (US) | 2012-10-24 | — | — | EP | disclosed |
| US-20110086819-A1 | NOVEL PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES | GRECO MICHAEL N | 2011-04-14 | — | — | US | disclosed |
| EP-1620446-A2 | PIPERAZINE CONTAINING PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES | Ortho-Mcneil Pharmaceutical Corp. (US) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004094441-A2 | PIPERAZINE CONTAINING PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2004-11-04 | — | — | WO | disclosed |
| EP-1438316-A1 | PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2004-07-21 | — | — | EP | disclosed |
| WO-2003035654-A1 | PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-05-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086819-A1 | NOVEL PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES | HPN, PRSS1, SERPINB1 | GPR183 4170/4885CYP1A2 4722/4885ALDH1A1 4232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.