Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.70 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.70 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.70 |
| ▸ | MAOA | P21397 | 1/20 | 0.70 |
| ▸ | HTR2B | P41595 | 1/20 | 0.70 |
| ▸ | ADRB1 | P08588 | 14/20 | 0.60 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.60 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.56 |
| ▸ | CASR | P41180 | 2/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11803062 | 0.89 | ADRB1 (0.72) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL11748169 | 0.88 | HTR1A (0.68) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL11954116 | 0.87 | HTR1A (0.64) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL11794422 | 0.86 | ADRB1 (0.66) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL11792446 | 0.86 | ADRB1 (0.66) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL10657060 | 0.86 | HTR1A (0.66) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL11790103 | 0.85 | ADRB1 (0.65) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL11798041 | 0.85 | ADRB1 (0.65) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL15677583 | 0.84 | HTR1A (0.66) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL10653746 | 0.84 | ADRB1 (0.64) | HTR1AADRA2AADRA2BMAOAHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155133-A | Antiarrhythmic compounds and pharmaceutical compositions and methods thereof | AKTIEBOLAGET HASSLE (SE) | 1992-10-13 | — | — | US | disclosed |
| WO-1989005794-A1 | NOVEL ANTIARRHYTHMIC AGENTS I | Aktiebolaget Hässle (SE) | 1989-06-29 | — | — | WO | disclosed |
| EP-0322390-A2 | Novel antiarrhythmic agents I | Aktiebolaget Hässle (SE) | 1989-06-28 | — | — | EP | disclosed |
| US-3732277-A | 1-(2'-CYANO-PHENOXY)-2-HYDROXY-3-ETHYLAMINO-PROPANE AND SALTS THEREOF | BOEHRINGER SOHN INGELHEIM | 1973-05-08 | — | — | US | disclosed |