Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15382467 | 0.92 | NAAA (0.47) | NAAAALDH1A1CYP3A4TSHRMAPK1 | |
| SCHEMBL13244921 | 0.88 | ALDH1A1 (0.51) | NAAAALDH1A1TSHRCASP3 | |
| SCHEMBL18712231 | 0.88 | ALDH1A1 (0.51) | NAAAALDH1A1TSHRCASP3 | |
| SCHEMBL7842024 | 0.81 | PREP (0.42) | ALDH1A1 | |
| SCHEMBL9655228 | 0.81 | KMT2A (0.48) | L3MBTL1 | |
| SCHEMBL9655226 | 0.81 | KMT2A (0.48) | L3MBTL1 | |
| SCHEMBL4700151 | 0.77 | ALDH1A1 (0.40) | ALDH1A1 | |
| SCHEMBL10437936 | 0.77 | ALDH1A1 (0.44) | NAAAALDH1A1CYP3A4TSHRMAPK1 | |
| SCHEMBL4698575 | 0.76 | ALDH1A1 (0.44) | ALDH1A1 | |
| SCHEMBL19027637 | 0.76 | KMT2A (0.50) | L3MBTL1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0318091-B1 | RESOLVED AMINO PYRROLIDINE NEUROPROTECTIVE AGENTS | MERCK SHARP & DOHME LTD. (GB) | 1992-12-09 | — | — | EP | disclosed |
| US-4863953-A | [3R]-3-amino-1-hydroxy pyrrolidin-2-one and its use as a neuroprotective agent | MERCK & CO., INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0318091-A2 | Resolved amino pyrrolidine neuroprotective agents | MERCK SHARP & DOHME LTD. (GB) | 1989-05-31 | — | — | EP | disclosed |