Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PNP | P00491 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10534501 | 0.92 | MAPK1 (0.43) | MAPK1KMT2ANPSR1ALDH1A1MEN1 | |
| SCHEMBL8805743 | 0.82 | ALDH1A1 (0.44) | MAPK1KMT2ANPSR1ALDH1A1MEN1 | |
| SCHEMBL18092890 | 0.70 | NPSR1 (0.49) | MAPK1KMT2ANPSR1ALDH1A1CYP1A2 | |
| SCHEMBL9653630 | 0.70 | NPSR1 (0.49) | MAPK1KMT2ANPSR1ALDH1A1MEN1 | |
| SCHEMBL718210 | 0.69 | NPSR1 (0.52) | MAPK1KMT2ANPSR1ALDH1A1CYP1A2 | |
| SCHEMBL12284639 | 0.69 | ALDH1A1 (0.65) | MAPK1KMT2ANPSR1ALDH1A1CYP1A2 | |
| SCHEMBL27875290 | 0.67 | ALDH1A1 (0.45) | KMT2ANPSR1ALDH1A1MEN1GAA | |
| SCHEMBL1687020 | 0.66 | XDH (0.49) | MAPK1KMT2ANPSR1ALDH1A1CYP1A2 | |
| SCHEMBL31661211 | 0.66 | MAPK1 (0.40) | MAPK1KMT2ANPSR1ALDH1A1MEN1 | |
| SCHEMBL10368407 | 0.66 | HTT (0.32) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303348-B1 | 2-AMINO-5-HYDROXY-4-PYRIMIDONES | PFIZER INC. (US) | 1992-01-08 | — | — | EP | disclosed |
| US-4910204-A | Treatment of leukotriene mediated pulmonary disorders, antihistamine, cardiovascular and gastrointestinal disorders; antiinflammatory agents | PFIZER INC. (US) | 1990-03-20 | — | — | US | disclosed |
| EP-0303348-A1 | 2-Amino-5-hydroxy-4-pyrimidones | PFIZER INC. (US) | 1989-02-15 | — | — | EP | disclosed |
| WO-1989000423-A1 | 2-AMINO-5-HYDROXY-4-PYRIMIDONES | PFIZER INC. (US) | 1989-01-26 | — | — | WO | disclosed |