Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PPID | Q08752 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9657962 | 0.96 | POLB (0.54) | POLBALDH1A1LMNANCEH1PTPN1 | |
| SCHEMBL9659401 | 0.95 | POLB (0.50) | POLBALDH1A1LMNANCEH1PTPN1 | |
| SCHEMBL9658483 | 0.87 | PTPN1 (0.52) | POLBALDH1A1LMNANCEH1PTPN1 | |
| SCHEMBL9659343 | 0.86 | FAAH (0.46) | POLBLMNANCEH1L3MBTL1FAAH | |
| SCHEMBL9656605 | 0.86 | NCEH1 (0.44) | POLBALDH1A1NCEH1MAPT | |
| SCHEMBL9659354 | 0.85 | FAAH (0.48) | LMNANCEH1L3MBTL1FAAHSMN1; SMN2 | |
| SCHEMBL9659327 | 0.84 | SLC2A1 (0.44) | POLBALDH1A1LMNAL3MBTL1RAB9A | |
| SCHEMBL9656320 | 0.84 | POLB (0.53) | POLBALDH1A1LMNANCEH1HPGD | |
| SCHEMBL9658031 | 0.84 | NCEH1 (0.54) | NCEH1L3MBTL1GAA | |
| SCHEMBL9654709 | 0.84 | NCEH1 (0.50) | ALDH1A1NCEH1PTPN1HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134161-A | Enzyme inhibitors for skin disorders, antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-4786652-A | TOPICAL ADMINISTRATION | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |