Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9656608 | 0.89 | KDM4E (0.47) | ALOX5KDM4ECYP2C9CYP1A2IDO1 | |
| SCHEMBL9656619 | 0.88 | ALOX5 (0.41) | ALOX5KDM4ECYP1A2ALDH1A1LMNA | |
| SCHEMBL9657849 | 0.83 | KDM4E (0.43) | ALOX5KDM4ECYP2C9CYP1A2IDO1 | |
| SCHEMBL9628241 | 0.83 | KDM4E (0.50) | ALOX5KDM4ECYP2C9CYP1A2IDO1 | |
| SCHEMBL30003343 | 0.82 | ALDH1A1 (0.52) | ALOX5KDM4EALDH1A1LMNAMAOB | |
| SCHEMBL19583364 | 0.82 | ALDH1A1 (0.52) | ALOX5KDM4EALDH1A1LMNAMAOB | |
| SCHEMBL9656655 | 0.80 | TSHR (0.49) | KDM4ECYP2C9CYP1A2IDO1ALDH1A1 | |
| SCHEMBL9658008 | 0.80 | ALDH1A1 (0.46) | ALOX5KDM4ECYP2C9CYP1A2IDO1 | |
| SCHEMBL9657106 | 0.79 | KDM4E (0.44) | KDM4ECYP2C9CYP1A2IDO1ALDH1A1 | |
| SCHEMBL9658456 | 0.79 | ALDH1A1 (0.45) | ALOX5KDM4ECYP2C9CYP1A2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134161-A | Enzyme inhibitors for skin disorders, antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-4786652-A | TOPICAL ADMINISTRATION | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |