Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TYMS | P04818 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CDC25B | P30305 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9657879 | 0.92 | KDM4E (0.50) | KDM4ECYP1A2CYP2C9IDO1ALDH1A1 | |
| SCHEMBL9657849 | 0.90 | KDM4E (0.43) | KDM4ECYP1A2CYP2C9IDO1ALDH1A1 | |
| SCHEMBL9656175 | 0.88 | TSHR (0.40) | KDM4ECYP1A2CYP2C9IDO1ALDH1A1 | |
| SCHEMBL12315084 | 0.87 | TSHR (0.47) | KDM4ECYP1A2CYP2C9IDO1ALDH1A1 | |
| SCHEMBL10643193 | 0.85 | KDM4E (0.54) | KDM4ECYP1A2CYP2C9IDO1ALDH1A1 | |
| SCHEMBL9657106 | 0.85 | KDM4E (0.44) | KDM4ECYP1A2CYP2C9IDO1ALDH1A1 | |
| SCHEMBL19583350 | 0.85 | TSHR (0.48) | KDM4EALDH1A1TSHRTYMSLMNA | |
| SCHEMBL30004235 | 0.85 | TSHR (0.48) | KDM4EALDH1A1TSHRTYMSLMNA | |
| SCHEMBL9659420 | 0.84 | KDM4E (0.47) | KDM4ECYP1A2CYP2C9IDO1ALDH1A1 | |
| SCHEMBL9659163 | 0.84 | KDM4E (0.43) | KDM4ECYP1A2CYP2C9IDO1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134161-A | Enzyme inhibitors for skin disorders, antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-4786652-A | TOPICAL ADMINISTRATION | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |