Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TYMS | P04818 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9657790 | 0.91 | ALDH1A1 (0.41) | TSHRCYP4F2CYP4A11PTGER4CYP1A2 | |
| SCHEMBL9656393 | 0.88 | KDM4E (0.46) | TSHRTYMSCYP4F2CYP4A11CYP1A2 | |
| SCHEMBL12315084 | 0.87 | TSHR (0.47) | TSHRTYMSCYP4F2CYP4A11CYP1A2 | |
| SCHEMBL9628321 | 0.86 | KDM4E (0.50) | TSHRPTGER4CYP1A2CYP2D6ALDH1A1 | |
| SCHEMBL9657819 | 0.85 | ALDH1A1 (0.40) | TSHRTYMSCYP4F2CYP4A11PTGER4 | |
| SCHEMBL10709274 | 0.85 | PIN1 (0.38) | TSHRCYP4F2CYP4A11PTGER4CYP1A2 | |
| SCHEMBL19583350 | 0.85 | TSHR (0.48) | TSHRTYMSCYP4F2CYP4A11MAOB | |
| SCHEMBL30004235 | 0.85 | TSHR (0.48) | TSHRTYMSCYP4F2CYP4A11MAOB | |
| SCHEMBL9627063 | 0.84 | ELANE (0.40) | TSHRCYP4F2CYP4A11PTGER4CYP1A2 | |
| SCHEMBL11008110 | 0.83 | CYP4F2 (0.38) | TSHRCYP4F2CYP4A11PTGER4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134161-A | Enzyme inhibitors for skin disorders, antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-4786652-A | TOPICAL ADMINISTRATION | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |