Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9658516 | 0.95 | KMT2A (0.44) | ABCB11MEN1GAAKMT2AKDM4E | |
| SCHEMBL9658201 | 0.91 | ABCB11 (0.45) | ABCB11MEN1GAAKMT2AKDM4E | |
| SCHEMBL9654743 | 0.86 | TSHR (0.45) | ALDH1A1ELANE | |
| SCHEMBL9658055 | 0.86 | ABCB11 (0.58) | ABCB11MEN1GAAKMT2AKDM4E | |
| SCHEMBL9657088 | 0.83 | ABCB11 (0.39) | ABCB11MEN1GAAKMT2AKDM4E | |
| SCHEMBL9659390 | 0.82 | TSHR (0.46) | ALDH1A1ELANE | |
| SCHEMBL9713400 | 0.82 | TOP2A (0.47) | ABCB11MEN1GAAKMT2AEPHX2 | |
| SCHEMBL9657928 | 0.81 | TSHR (0.45) | GAAALDH1A1ELANE | |
| SCHEMBL9654671 | 0.81 | ABCB11 (0.60) | ABCB11MEN1GAAKMT2AKDM4E | |
| SCHEMBL9658382 | 0.81 | ELANE (0.47) | MEN1KMT2AKDM4EALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134161-A | Enzyme inhibitors for skin disorders, antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-4786652-A | TOPICAL ADMINISTRATION | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |