Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 3/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10644830 | 0.92 | ABCB11 (0.43) | ABCB1NR4A2ABCB11ALDH1A1PGR | |
| SCHEMBL9627436 | 0.86 | ABCB11 (0.52) | ABCB1NR4A2ABCB11ALDH1A1GAA | |
| SCHEMBL9654788 | 0.85 | ALDH1A1 (0.47) | ABCB11ALDH1A1PGRGAAPTGS1 | |
| SCHEMBL9659442 | 0.82 | KDM4E (0.51) | ABCB11ALDH1A1PGRGAAPTGS1 | |
| SCHEMBL9659855 | 0.82 | ALDH1A1 (0.47) | ALDH1A1PGRGAAPTGS1MAPK1 | |
| SCHEMBL9656365 | 0.81 | ABCB11 (0.40) | ABCB1NR4A2ABCB11ALDH1A1KDM4E | |
| SCHEMBL9657798 | 0.81 | ABCB11 (0.59) | NR4A2ABCB11ALDH1A1KDM4EMCL1 | |
| SCHEMBL9658299 | 0.81 | ABCB11 (0.40) | ABCB11ALDH1A1PGRGAAPTGS1 | |
| SCHEMBL9654673 | 0.81 | ABCB11 (0.59) | NR4A2ABCB11ALDH1A1KDM4EMCL1 | |
| SCHEMBL9658179 | 0.79 | ABCB11 (0.46) | ABCB1NR4A2ABCB11HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134161-A | Enzyme inhibitors for skin disorders, antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-4786652-A | TOPICAL ADMINISTRATION | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |