Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.51 |
| ▸ | IDH2 | P48735 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL967254 | 0.85 | SMN1; SMN2 (0.63) | TP53SMN1; SMN2KDM4EGAAMEN1 | |
| SCHEMBL31093984 | 0.83 | SMN1; SMN2 (0.63) | TP53SMN1; SMN2KDM4EGAAMEN1 | |
| SCHEMBL5561958 | 0.83 | SMN1; SMN2 (0.63) | TP53SMN1; SMN2KDM4EGAAMEN1 | |
| SCHEMBL963688 | 0.81 | SMN1; SMN2 (0.62) | TP53SMN1; SMN2KDM4EGAAMEN1 | |
| SCHEMBL5133570 | 0.81 | SMN1; SMN2 (0.62) | TP53SMN1; SMN2KDM4EGAAMEN1 | |
| SCHEMBL23733551 | 0.80 | SMN1; SMN2 (0.60) | TP53SMN1; SMN2KDM4EGAAMEN1 | |
| SCHEMBL967252 | 0.80 | ALDH1A1 (0.61) | TP53SMN1; SMN2KDM4EGAAMEN1 | |
| SCHEMBL19638131 | 0.80 | SMN1; SMN2 (0.60) | TP53SMN1; SMN2KDM4EGAAMEN1 | |
| SCHEMBL12251335 | 0.80 | SMN1; SMN2 (0.60) | TP53SMN1; SMN2KDM4EGAAMEN1 | |
| SCHEMBL3034787 | 0.80 | SMN1; SMN2 (0.60) | TP53SMN1; SMN2KDM4EGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110021525-A1 | P70S6 Kinase Modulators and Method of Use | EXELIXIS, INC. (US) | 2011-01-27 | — | — | US | disclosed |
| US-7816353-B2 | P70S6 kinase modulators and method of use | EXELIXIS, INC. (US) | 2010-10-19 | — | — | US | disclosed |
| US-20070208020-A1 | P70S6 Kinase Modulators And Method Of Use | EXELIXIS, INC. | 2007-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021525-A1 | P70S6 Kinase Modulators and Method of Use | EEF2K, RPS6KA3, MTOR | TP53 1327/4885SMN1; SMN2 2850/4885KDM4E 1347/4885 |
| US-20070208020-A1 | P70S6 Kinase Modulators And Method Of Use | EEF2K, RPS6KA3, MTOR | TP53 1327/4885SMN1; SMN2 2850/4885KDM4E 1347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.