Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | FASN | P49327 | 1/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9656569 | 0.79 | EP300 (0.47) | EP300ALOX5PTGS2LMNAERN1 | |
| SCHEMBL9656536 | 0.79 | HIF1A (0.46) | EP300ALOX5PTGS2LMNAERN1 | |
| SCHEMBL9656641 | 0.79 | ESR1 (0.40) | ALOX5FASNLMNAMAPTKDM4E | |
| SCHEMBL2024877 | 0.75 | TUBB1 (0.47) | EP300TUBB1CA1CA2TUBB4A | |
| SCHEMBL9054405 | 0.75 | EP300 (0.67) | EP300LMNACA12CA1CA2 | |
| SCHEMBL29700325 | 0.75 | EP300 (0.67) | EP300LMNACA12CA1CA2 | |
| SCHEMBL9657079 | 0.75 | HIF1A (0.50) | EP300TUBB1CA12CA1CA2 | |
| SCHEMBL9627440 | 0.74 | TNFSF11 (0.50) | PTGS2LMNACA12CA1CA2 | |
| SCHEMBL22295272 | 0.73 | ALDH1A1 (0.43) | EP300ALOX5PTGS2LMNACA12 | |
| SCHEMBL9627649 | 0.73 | HTT (0.50) | ALOX5FASNTUBB1TUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134161-A | Enzyme inhibitors for skin disorders, antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-4786652-A | TOPICAL ADMINISTRATION | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |