Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 2/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9658066 | 0.91 | ABCB11 (0.74) | ABCB11KDM4ECYP1A2CYP2C9IDO1 | |
| SCHEMBL9629374 | 0.87 | ABCB11 (0.83) | ABCB11KDM4ECYP1A2CYP2C9IDO1 | |
| SCHEMBL9654917 | 0.87 | ABCB11 (0.50) | ABCB11KDM4EALDH1A1HPGDPOLB | |
| SCHEMBL9657798 | 0.86 | ABCB11 (0.59) | ABCB11KDM4ENR4A2CMA1TUBB4A | |
| SCHEMBL9654673 | 0.86 | ABCB11 (0.59) | ABCB11KDM4ENR4A2CMA1TUBB4A | |
| SCHEMBL9627469 | 0.84 | ABCB11 (0.83) | ABCB11KDM4ECYP1A2CYP2C9IDO1 | |
| SCHEMBL9628214 | 0.84 | ABCB11 (0.78) | ABCB11KDM4ENR4A2TUBB4ATUBB | |
| SCHEMBL9713544 | 0.83 | ABCB11 (0.59) | ABCB11NR4A2CMA1TUBB4ATUBB | |
| SCHEMBL9713746 | 0.83 | ABCB11 (0.59) | ABCB11KDM4ECYP1A2CYP2C9MAPK1 | |
| SCHEMBL9657901 | 0.83 | ABCB11 (0.56) | ABCB11CYP1A2TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134161-A | Enzyme inhibitors for skin disorders, antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-4786652-A | TOPICAL ADMINISTRATION | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |