Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 16/20 | 0.48 |
| ▸ | MAPT | P10636 | 16/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1600055 | 0.82 | ALDH1A1 (0.50) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL2472187 | 0.82 | ALDH1A1 (0.50) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL4632526 | 0.80 | ALDH1A1 (0.48) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL1600420 | 0.77 | ALDH1A1 (0.46) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL15488864 | 0.75 | ALDH1A1 (0.50) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL3825706 | 0.75 | HSPA5 (0.53) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL14354290 | 0.74 | MAPT (0.60) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL13296256 | 0.73 | ALDH1A1 (0.52) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL27503707 | 0.72 | MEN1 (0.52) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL27567617 | 0.72 | MEN1 (0.52) | ALDH1A1MAPTKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114851-A | Serine- or cysteine-containing protease modified by nucleophilic cinnamic acid; photoisomerization; biological switches; medical diagnosis | DUKE UNIVERSITY (US) | 1992-05-19 | — | — | US | disclosed |