Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.55 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.55 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | CDK9 | P50750 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.50 |
| ▸ | RELA | Q04206 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9659168 | 1.00 | MAPT (0.55) | MAPTTDP1CCNT1CCNE2GAA | |
| SCHEMBL10918836 | 0.83 | MAPT (0.44) | MAPTTDP1CCNT1CCNE2GAA | |
| SCHEMBL10918835 | 0.83 | MAPT (0.44) | MAPTTDP1CCNT1CCNE2GAA | |
| SCHEMBL10708407 | 0.79 | MAPT (0.64) | MAPTTDP1CCNT1CCNE2GAA | |
| SCHEMBL10708396 | 0.79 | MAPT (0.64) | MAPTTDP1CCNT1CCNE2GAA | |
| SCHEMBL5310168 | 0.79 | MAPT (0.50) | MAPTTDP1CCNT1CCNE2GAA | |
| SCHEMBL10408855 | 0.74 | ALDH1A1 (0.80) | MAPTTDP1CCNT1CCNE2GAA | |
| Azobenzene SCHEMBL28756037 | 0.71 | ALDH1A1 (0.86) | MAPTTDP1CCNT1CCNE2GAA | |
| SCHEMBL10918165 | 0.71 | ALDH1A1 (0.44) | MAPTTDP1CCNT1CCNE2GAA | |
| SCHEMBL10918162 | 0.71 | ALDH1A1 (0.44) | MAPTTDP1CCNT1CCNE2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4092314-A | FROM ARYLAZOMALONONITRILE AND FORMAMIDE AND AMMONIA, AMMONIUM SALT | MERCK & CO., INC. (US) | 1978-05-30 | — | — | US | claimed |
| CN-118217290-B | Use of soluble guanylate cyclase stimulators for the prevention and treatment of altitude pulmonary oedema | 中国人民解放军军事科学院军事医学研究院 | 2024-10-29 | — | — | CN | disclosed |
| CN-117924280-B | Substituted thienyl-5-fluoro-1H-pyrazolopyridine compound and application thereof | 中国人民解放军军事科学院军事医学研究院 | 2024-07-12 | — | — | CN | disclosed |
| CN-118217290-A | Use of soluble guanylate cyclase stimulators for the prevention and treatment of altitude pulmonary oedema | 中国人民解放军军事科学院军事医学研究院 | 2024-06-21 | — | — | CN | disclosed |
| CN-117924280-A | Substituted thienyl-5-fluoro-1H-pyrazolopyridine compound and application thereof | 中国人民解放军军事科学院军事医学研究院 | 2024-04-26 | — | — | CN | disclosed |
| US-5089618-A | Converting to N,N'-Bis(trimethylsilyl)derivative; distillation; solvolytic cleavage; hydrolysis; efficiency; high purity | LONZA LTD. (CH) | 1992-02-18 | — | — | US | disclosed |
| US-4997939-A | Reduction, cyclization | KOHJIN CO., LTD. (JP) | 1991-03-05 | — | — | US | disclosed |
| US-4861883-A | REACTING ARYLAZONONITRILE WITH FORMIC ACID IN PRESENCE OF AMMONIA, CYCLIZATION, REMOVAL AMMONIA, THEN CATALYTIC REDUCTION | KOHJIN CO., LTD. (JP) | 1989-08-29 | — | — | US | disclosed |
| EP-0118597-B1 | PROCESS FOR PREPARING ADENINE | Kohjin Co., Ltd. (JP) | 1987-04-08 | — | — | EP | disclosed |
| US-4503228-A | 2-(Pyridinyl)-4,5,6-pyrimidinetriamines | STERLING DRUG INC. (US) | 1985-03-05 | — | — | US | disclosed |
| EP-0045503-B1 | PROCESS FOR PREPARING ADENINE | Kohjin Co., Ltd. (JP) | 1984-11-14 | — | — | EP | disclosed |
| US-4473571-A | 8-Substituted-2-(4-pyridinyl)-9H-purin-6-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1984-09-25 | — | — | US | disclosed |
| EP-0118597-A2 | Process for preparing adenine | Kohjin Co., Ltd. (JP) | 1984-09-19 | — | — | EP | disclosed |
| EP-0045503-A1 | Process for preparing adenine | Kohjin Co., Ltd. (JP) | 1982-02-10 | — | — | EP | disclosed |
| US-4092314-A | FROM ARYLAZOMALONONITRILE AND FORMAMIDE AND AMMONIA, AMMONIUM SALT | MERCK & CO., INC. (US) | 1978-05-30 | — | — | US | disclosed |