Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 5/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9660282 | 1.00 | LMNA (0.46) | LMNACYP2D6ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL9658896 | 0.83 | LMNA (0.50) | LMNACYP2D6ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL9658892 | 0.83 | LMNA (0.50) | LMNACYP2D6ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL9660894 | 0.83 | LMNA (0.46) | LMNACYP2D6KDM4EL3MBTL1AOC3 | |
| SCHEMBL9660899 | 0.83 | LMNA (0.46) | LMNACYP2D6KDM4EL3MBTL1AOC3 | |
| SCHEMBL11078941 | 0.81 | AOC3 (0.46) | LMNACYP2D6ALDH1A1KDM4EAOC3 | |
| SCHEMBL9661177 | 0.80 | LMNA (0.43) | LMNACYP2D6KDM4EL3MBTL1AOC3 | |
| SCHEMBL9661183 | 0.80 | LMNA (0.43) | LMNACYP2D6KDM4EL3MBTL1AOC3 | |
| SCHEMBL9661017 | 0.79 | RIPK1 (0.44) | LMNACYP2D6KDM4EL3MBTL1AOC3 | |
| SCHEMBL9661024 | 0.79 | RIPK1 (0.44) | LMNACYP2D6KDM4EL3MBTL1AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5080719-A | Pyrazine derivatives | PHILIP MORRIS INCORPORATED (US) | 1992-01-14 | — | — | US | disclosed |
| EP-0309203-A2 | Flavorant-release additives and compositions containing them | Philip Morris Products Inc. (US) | 1989-03-29 | — | — | EP | disclosed |