Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9054124 | 0.86 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2KMT2APOLB | |
| SCHEMBL3026432 | 0.77 | KMT2A (0.54) | NPC1RAB9ASMN1; SMN2KMT2APOLB | |
| SCHEMBL13214828 | 0.77 | KMT2A (0.54) | NPC1RAB9ASMN1; SMN2KMT2APOLB | |
| SCHEMBL11770529 | 0.77 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2KMT2APOLB | |
| SCHEMBL967734 | 0.76 | POLB (0.36) | NPC1RAB9ASMN1; SMN2KMT2APOLB | |
| SCHEMBL3022175 | 0.75 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2KMT2APOLB | |
| SCHEMBL14058963 | 0.74 | ALDH1A1 (0.38) | NPC1RAB9ASMN1; SMN2KMT2APOLB | |
| SCHEMBL3022086 | 0.74 | KMT2A (0.50) | NPC1RAB9ASMN1; SMN2KMT2APOLB | |
| SCHEMBL3027021 | 0.72 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2KMT2APOLB | |
| SCHEMBL3029188 | 0.72 | MAPT (0.51) | NPC1RAB9ASMN1; SMN2KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120323001-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2012-12-20 | — | — | US | disclosed |
| US-8278441-B2 | BACE inhibitors | ELI LILLY AND COMPANY (US) | 2012-10-02 | — | — | US | disclosed |
| US-20110009395-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120323001-A1 | BACE INHIBITORS | BACE1, BACE2, APP | NPC1 13/4885RAB9A 1341/4885SMN1; SMN2 961/4885 |
| US-20110009395-A1 | BACE INHIBITORS | BACE1, BACE2, APP | NPC1 13/4885RAB9A 1341/4885SMN1; SMN2 961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.