Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | THRA | P10827 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NAAA | Q02083 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29057552 | 0.89 | MAPT (0.66) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL713464 | 0.89 | MAPT (0.66) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL765851 | 0.89 | MAPT (0.66) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL9663089 | 0.89 | MAPT (0.66) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL3249491 | 0.87 | MAPT (0.62) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL7337631 | 0.87 | TAAR1 (0.57) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL5101251 | 0.85 | HDAC3 (0.63) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL456436 | 0.85 | FFAR4 (0.67) | FFAR4THRATHRBFFAR1 | |
| SCHEMBL7507667 | 0.83 | MMP12 (0.54) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| Sebacic Acid SCHEMBL9311898 | 0.82 | HDAC11 (0.52) | HDAC3HDAC1HDAC2HDAC10HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273451-B1 | LIPOXYGENASE INHIBITORY COMPOUNDS | Bristol-Myers Squibb Company (US) | 1992-04-01 | — | — | EP | disclosed |
| US-4861798-A | Lipoxygenase inhibitory compounds | BRISTOL-MYERS COMPANY (US) | 1989-08-29 | — | — | US | disclosed |
| EP-0273451-A2 | Lipoxygenase inhibitory compounds | Bristol-Myers Squibb Company (US) | 1988-07-06 | — | — | EP | disclosed |