SCHEMBL456436

SCHEMBL456436

Cc1cccc(CCC(=O)O)c1

nearest known ligand 0.67

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 3/20 0.67
THRA P10827 1/20 0.62
THRB P10828 1/20 0.62
FFAR1 O14842 6/20 0.62
KEAP1 Q14145 1/20 0.61
PTPRB P23467 1/20 0.57
CDC25A P30304 1/20 0.57
CDC25B P30305 1/20 0.57
PTEN P60484 1/20 0.57
PTPMT1 Q8WUK0 1/20 0.57
TAAR1 Q96RJ0 1/20 0.55
CTBP2 P56545 1/20 0.51
PLA2G10 O15496 2/20 0.51
KDM4E B2RXH2 1/20 0.50
MEN1 O00255 1/20 0.50
ALDH1A1 P00352 1/20 0.50
LMNA P02545 1/20 0.50
KMT2A Q03164 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dimethylamine SCHEMBL9871069 0.95 FFAR4 (0.62) FFAR4THRATHRBFFAR1KEAP1
SCHEMBL13525204 0.90 FFAR1 (0.71) FFAR4THRATHRBFFAR1KEAP1
SCHEMBL5101251 0.89 HDAC3 (0.63) FFAR4THRATHRBFFAR1TAAR1
SCHEMBL3249491 0.87 MAPT (0.62) FFAR4THRATHRBFFAR1
SCHEMBL7337631 0.86 TAAR1 (0.57) FFAR4THRATHRBFFAR1TAAR1
Phenyl Propionic Acid SCHEMBL28551157 0.86 FFAR4 (0.57) FFAR4THRATHRBFFAR1KEAP1
SCHEMBL29057552 0.86 MAPT (0.66) FFAR4
SCHEMBL9663089 0.86 MAPT (0.66) FFAR4
SCHEMBL7507667 0.86 MMP12 (0.54) FFAR4THRATHRBFFAR1TAAR1
SCHEMBL765851 0.86 MAPT (0.66) FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 279 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12304894-B2 Derivatives of adamantyl oxadiazoles and pharmaceutically acceptable solvates, hydrates and salts thereof, pharmaceutical composition comprising same, synthesis method, suitable for use as effective and selective inhibitors of the reductase activity of the enzyme 11-beta dehydrogenase type 1 (11β-HSD1) PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE (CL) 2025-05-20 US claimed
CN-118184679-A Photothermal agent and preparation method thereof, photothermal nanoparticle and preparation method thereof, insulating material and self-repairing method of insulating material 中国石油天然气股份有限公司 2024-06-14 CN claimed
US-20220194909-A1 DERIVATIVES OF ADAMANTYL OXADIAZOLES AND PHARMACEUTICALLY ACCEPTABLE SOLVATES, HYDRATES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITION COMPRISING SAME, SYNTHESIS METHOD, SUITABLE FOR USE AS EFFECTIVE AND SELECTIVE INHIBITORS OF THE REDUCTASE ACTIVITY OF THE ENZYME 11-BETA DEHYDROGENASE TYPE 1 (11B-HSD1) PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE (CL) 2022-06-23 US claimed
CN-110167933-B As αVAzole amides and amines as integrin inhibitors 百时美施贵宝公司 2022-06-21 CN claimed
WO-2020210922-A1 DERIVATIVES OF ADAMANTYL OXADIAZOLES AND PHARMACEUTICALLY ACCEPTABLE SOLVATES, HYDRATES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITION COMPRISING SAME, SYNTHESIS METHOD, SUITABLE FOR USE AS EFFECTIVE AND SELECTIVE INHIBITORS OF THE REDUCTASE ACTIVITY OF THE ENZYME 11-BETA DEHYDROGENASE TYPE 1 (11Β-HSD1) PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE (CL) 2020-10-22 WO claimed
US-7951765-B2 Photoresist stripper composition for semiconductor manufacturing TECHNO SEMICHEM CO., LTD. (KR) 2011-05-31 US claimed
EP-1913448-B1 PHOTORESIST STRIPPER COMPOSITION FOR SEMICONDUCTOR MANUFACTURING TECHNO SEMICHEM CO LTD (KR) 2010-10-13 EP claimed
US-20090312216-A1 Photoresist Stripper Composition for Semiconductor Manufacturing TECHNO SEMICHEM CO., LTD. (KR) 2009-12-17 US claimed
EP-1913448-A4 PHOTORESIST STRIPPER COMPOSITION FOR SEMICONDUCTOR MANUFACTURING TECHNO SEMICHEM CO LTD (KR) 2008-11-05 EP claimed
EP-1913448-A1 PHOTORESIST STRIPPER COMPOSITION FOR SEMICONDUCTOR MANUFACTURING Techno Semichem Co., Ltd. (KR) 2008-04-23 EP claimed
WO-2007021085-A1 PHOTORESIST STRIPPER COMPOSITION FOR SEMICONDUCTOR MANUFACTURING TECHNO SEMICHEM CO., LTD. (KR) 2007-02-22 WO claimed
WO-1996027369-A9 COMPOSITIONS FOR THE TREATMENT OF BLOOD DISORDERS 1996-12-27 WO claimed
US-20260049060-A1 TETRAHYDROISOQUINOLINYLMETHYLBENZAMIDE COMPOUNDS NATIONAL HEALTH RES INST (TW) 2026-02-19 US disclosed
US-12428403-B2 N-(heterocyclyl and heterocyclylalkyl)-3-benzylpyridin-2-amine derivatives as SSTR4 agonists TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2025-09-30 US disclosed
US-12404265-B2 Substituted pyridine derivatives as SARM1 inhibitors NURA BIO, INC. (US) 2025-09-02 US disclosed
US-12304894-B2 Derivatives of adamantyl oxadiazoles and pharmaceutically acceptable solvates, hydrates and salts thereof, pharmaceutical composition comprising same, synthesis method, suitable for use as effective and selective inhibitors of the reductase activity of the enzyme 11-beta dehydrogenase type 1 (11β-HSD1) PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE (CL) 2025-05-20 US disclosed
EP-0393668-B1 Method of preparation of benzaldehyde dialkyl acetals and new benzaldehyde dialkyl acetals BASF AG (DE) 1994-02-02 EP disclosed
US-5276049-A Treatment of thrombosis DR. KARL THOMAE GMBH (DE) 1994-01-04 US disclosed
EP-0503548-A1 Cyclic urea derivatives, medicaments contaning them and process for their preparation Dr. Karl Thomae GmbH (DE) 1992-09-16 EP disclosed
EP-0393668-A2 Method of preparation of benzaldehyde dialkyl acetals and new benzaldehyde dialkyl acetals BASF Aktiengesellschaft (DE) 1990-10-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12404265-B2 Substituted pyridine derivatives as SARM1 inhibitors SARM1, SARNP, ADRM1 FFAR4 4580/4885THRA 4180/4885THRB 3382/4885
US-20260049060-A1 TETRAHYDROISOQUINOLINYLMETHYLBENZAMIDE COMPOUNDS OPRK1, OPRD1, OPRM1 FFAR4 882/4885THRA 99/4885THRB 77/4885
US-12428403-B2 N-(heterocyclyl and heterocyclylalkyl)-3-benzylpyridin-2-amine derivatives as SSTR4 agonists SSTR4, SSTR3, SSTR1 FFAR4 98/4885THRA 281/4885THRB 314/4885
US-20220194909-A1 DERIVATIVES OF ADAMANTYL OXADIAZOLES AND PHARMACEUTICALLY ACCEPTABLE SOLVATES, HYDRATES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITION COMPRISING SAME, SYNTHESIS METHOD, SUITABLE FOR USE AS EFFECTIVE AND SELECTIVE INHIBITORS OF THE REDUCTASE ACTIVITY OF THE ENZYME 11-BETA DEHYDROGENASE TYPE 1 (11B-HSD1) HSD11B1, HSD11B2, CYP11B1 FFAR4 1638/4885THRA 3054/4885THRB 1918/4885
US-12304894-B2 Derivatives of adamantyl oxadiazoles and pharmaceutically acceptable solvates, hydrates and salts thereof, pharmaceutical composition comprising same, synthesis method, suitable for use as effective and selective inhibitors of the reductase activity of the enzyme 11-beta dehydrogenase type 1 (11β-HSD1) HSD11B1, HSD11B2, HSD17B1 FFAR4 1493/4885THRA 2803/4885THRB 1973/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.