Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9663109 | 0.86 | MAPK1 (0.51) | MAPK1ALDH1A1POLBFKBP1A | |
| SCHEMBL9662545 | 0.82 | MCL1 (0.45) | MAPK1ALDH1A1HPGDPOLB | |
| SCHEMBL11728918 | 0.81 | F2RL1 (0.57) | MAPK1ALDH1A1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL26637816 | 0.80 | ALDH1A1 (0.60) | ALDH1A1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7920767 | 0.79 | MAPK1 (1.00) | MAPK1ALDH1A1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL7638791 | 0.76 | KMT2A (0.47) | MAPK1ALDH1A1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL9663967 | 0.76 | MCL1 (0.43) | MAPK1KMT2APOLB | |
| SCHEMBL535049 | 0.73 | MCL1 (0.46) | MAPK1ALDH1A1KMT2ACYP2D6HPGD | |
| SCHEMBL5270856 | 0.73 | MAPK1 (0.73) | MAPK1ALDH1A1KMT2AHPGDPOLB | |
| SCHEMBL10191436 | 0.73 | ALDH1A1 (0.57) | MAPK1ALDH1A1CYP1A2CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273451-B1 | LIPOXYGENASE INHIBITORY COMPOUNDS | Bristol-Myers Squibb Company (US) | 1992-04-01 | — | — | EP | disclosed |
| US-4861798-A | Lipoxygenase inhibitory compounds | BRISTOL-MYERS COMPANY (US) | 1989-08-29 | — | — | US | disclosed |