Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.45 |
| ▸ | PPARD | Q03181 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | KLK1 | P06870 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9665771 | 0.78 | PPARD (0.49) | MAPK14PPARDMAPTMEN1ALDH1A1 | |
| SCHEMBL7621279 | 0.78 | MAPK14 (0.51) | MAPK14NPC1RAB9APPARDMAPT | |
| SCHEMBL9666206 | 0.77 | CYP19A1 (0.49) | NPC1RAB9APPARDMAPTMEN1 | |
| SCHEMBL9664443 | 0.76 | MEN1 (0.46) | MAPK14HSD17B10NPC1TP53RAB9A | |
| SCHEMBL9666106 | 0.75 | MAPT (0.46) | MAPK14PPARDMAPTMEN1ALDH1A1 | |
| SCHEMBL9665564 | 0.75 | CYP19A1 (0.47) | NPC1RAB9APPARDMAPTALDH1A1 | |
| SCHEMBL9663895 | 0.74 | CYP19A1 (0.45) | NPC1RAB9APPARDMAPTALDH1A1 | |
| SCHEMBL9666309 | 0.74 | ALOX5 (0.58) | NPC1RAB9AMAPTMEN1ALDH1A1 | |
| SCHEMBL9664437 | 0.74 | MAPT (0.43) | HSD17B10PPARDMAPTMEN1ALDH1A1 | |
| SCHEMBL9665388 | 0.74 | HCRTR1 (0.49) | MAPK14HSD17B10NPC1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0149884-B1 | 5-PYRIDYL-1,3-THIAZOLE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1992-12-16 | — | — | EP | disclosed |
| US-4612321-A | 5-pyridyl-1,3-thiazole derivatives | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 1986-09-16 | — | — | US | disclosed |
| EP-0149884-A2 | 5-Pyridyl-1,3-thiazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1985-07-31 | — | — | EP | disclosed |