Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.96 |
| ▸ | GAA | P10253 | 1/20 | 0.91 |
| ▸ | MAPT | P10636 | 1/20 | 0.75 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.52 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.49 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.44 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9667551 | 0.98 | GAA (0.95) | TSHRGAAMAPTRECQLALDH1A1 | |
| SCHEMBL2956572 | 0.88 | — | — | |
| SCHEMBL9093412 | 0.81 | TSHR (0.66) | TSHRGAAMAPTRECQLALDH1A1 | |
| SCHEMBL16254880 | 0.81 | TSHR (0.66) | TSHRGAAMAPTRECQLALDH1A1 | |
| SCHEMBL6185245 | 0.78 | GAA (0.64) | TSHRGAAMAPTRECQLALDH1A1 | |
| SCHEMBL15730586 | 0.78 | GAA (0.64) | TSHRGAAMAPTRECQLALDH1A1 | |
| SCHEMBL16254691 | 0.78 | GAA (0.64) | TSHRGAAMAPTRECQLALDH1A1 | |
| SCHEMBL15730093 | 0.78 | GAA (0.64) | TSHRGAAMAPTRECQLALDH1A1 | |
| SCHEMBL16468542 | 0.77 | RECQL (0.88) | TSHRGAAMAPTRECQLALDH1A1 | |
| SCHEMBL16723246 | 0.77 | TSHR (0.64) | TSHRGAAMAPTRECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273647-B1 | COUMARAN DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1992-03-11 | — | — | EP | disclosed |
| US-4857516-A | Coumaran derivatives and their pharmaceutical use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-08-15 | — | — | US | disclosed |
| EP-0273647-A1 | Coumaran derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1988-07-06 | — | — | EP | disclosed |