Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.40 |
| ▸ | CNR1 | P21554 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16723230 | 0.77 | TSHR (0.37) | TSHRGAAMAPTRECQL | |
| SCHEMBL9667146 | 0.77 | TSHR (0.96) | TSHRGAAMAPTRECQLGRM1 | |
| SCHEMBL16723248 | 0.75 | HSD11B1 (0.43) | TSHRGAAHSD11B1ALDH1A1LMNA | |
| SCHEMBL9667551 | 0.74 | GAA (0.95) | TSHRGAAMAPTRECQLBRD4 | |
| SCHEMBL16722934 | 0.73 | GAA (0.40) | TSHRGAAMAPTRECQLCNR1 | |
| SCHEMBL16723222 | 0.73 | TSHR (0.36) | TSHRGAAHSD11B1 | |
| SCHEMBL16723104 | 0.72 | GAA (0.35) | TSHRGAAMAPT | |
| SCHEMBL16723162 | 0.72 | IDH1 (0.37) | TSHRGAAALDH1A1 | |
| SCHEMBL16723195 | 0.70 | GAA (0.32) | TSHRGAA | |
| SCHEMBL16723170 | 0.70 | GAA (0.32) | TSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015074081-A1 | BENZOPIPERAZINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS | BAIR KENNETH W (US) | 2015-05-21 | — | — | WO | disclosed |