Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.69 |
| ▸ | DRD2 | P14416 | 4/20 | 0.66 |
| ▸ | DRD4 | P21917 | 1/20 | 0.60 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | UBE2M | P61081 | 2/20 | 0.56 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.56 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 2/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6351172 | 0.93 | CHRM4 (0.61) | CHRM4DRD2DRD4GRM2SIGMAR1 | |
| SCHEMBL11403534 | 0.86 | CNR2 (0.60) | CHRM4DRD2DRD4SIGMAR1MEN1 | |
| Hydrochloric Acid SCHEMBL11398713 | 0.85 | CNR2 (0.58) | CHRM4DRD2DRD4SIGMAR1MEN1 | |
| SCHEMBL31328453 | 0.84 | CHRM4 (0.54) | CHRM4DRD2DRD4GRM2SIGMAR1 | |
| SCHEMBL31328410 | 0.83 | CHRM4 (0.52) | CHRM4DRD2DRD4GRM2SIGMAR1 | |
| SCHEMBL29432193 | 0.83 | CHRM4 (1.00) | CHRM4 | |
| SCHEMBL6184654 | 0.81 | CHRM4 (0.59) | CHRM4DRD2SIGMAR1TRPV6 | |
| SCHEMBL1002852 | 0.81 | MEN1 (0.81) | CHRM4DRD2DRD4SIGMAR1MEN1 | |
| SCHEMBL9482766 | 0.81 | DRD2 (0.54) | CHRM4DRD2SIGMAR1MEN1KMT2A | |
| SCHEMBL7404986 | 0.80 | DRD2 (0.61) | CHRM4DRD2DRD4GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153206-A | Neuroleptic agents for treating psychological disorders | PFIZER INC. (US) | 1992-10-06 | — | — | US | disclosed |
| WO-1990006303-A1 | ARYLPIPERIDINE DERIVATIVES | PFIZER INC. (US) | 1990-06-14 | — | — | WO | disclosed |