Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 4/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | CBFB | Q13951 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | GCK | P35557 | 2/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9667403 | 0.81 | PDE3B (0.43) | KDM4EHPGDGSK3BMAPK9MAPK10 | |
| SCHEMBL9670178 | 0.80 | CYP19A1 (0.52) | ALDH1A1BTK | |
| SCHEMBL9668918 | 0.76 | KDM4E (0.36) | KDM4EHPGDNPC1ALDH1A1LMNA | |
| SCHEMBL28784366 | 0.75 | ITK (0.57) | KDM4EHPGDNPC1ALDH1A1LMNA | |
| SCHEMBL9669274 | 0.72 | CHRNA7 (0.44) | KDM4EHPGDALDH1A1MAPTTSHR | |
| SCHEMBL10554267 | 0.70 | SMN1; SMN2 (0.47) | KDM4EHPGDNPC1ALDH1A1LMNA | |
| SCHEMBL308319 | 0.70 | GSK3B (0.61) | KDM4EHPGDNPC1ALDH1A1LMNA | |
| SCHEMBL29470995 | 0.70 | GSK3B (0.61) | KDM4EHPGDNPC1ALDH1A1LMNA | |
| SCHEMBL1466825 | 0.69 | SMN1; SMN2 (0.55) | KDM4EHPGDNPC1ALDH1A1LMNA | |
| SCHEMBL31317744 | 0.68 | CYP11B1 (0.50) | KDM4ENPC1RAB9ASMN1; SMN2ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0223937-B1 | INDOLES SUBSTITUTED WITH HETEROCYCLES, INTERMEDIATES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS | Roche Diagnostics GmbH (DE) | 1992-03-18 | — | — | EP | disclosed |
| US-4851406-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE | BOEHRINGER MANNHEIM GMBH (DE) | 1989-07-25 | — | — | US | disclosed |