Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4858398 | 0.77 | ACHE (0.56) | ACHE | |
| SCHEMBL4853298 | 0.73 | ACHE (0.55) | ACHE | |
| SCHEMBL10519759 | 0.71 | ACHE (0.44) | ACHE | |
| Hydrochloric Acid SCHEMBL10521614 | 0.71 | ACHE (0.43) | ACHE | |
| SCHEMBL12043675 | 0.71 | ACHE (0.50) | ACHEKDM4EALDH1A1KMT2A | |
| SCHEMBL10854754 | 0.70 | ACHE (0.49) | ACHEKDM4EALDH1A1KMT2A | |
| SCHEMBL10645687 | 0.67 | MAOA (0.45) | ACHEALDH1A1KMT2A | |
| SCHEMBL10848767 | 0.64 | SRC (0.40) | KMT2A | |
| SCHEMBL10200127 | 0.64 | CYP3A4 (0.49) | ACHEKDM4EALDH1A1KMT2A | |
| SCHEMBL10656149 | 0.63 | GRM2 (0.45) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259793-B1 | NAPHTHYL DERIVATIVES, MEDICAMENTS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1992-07-01 | — | — | EP | disclosed |
| US-4871735-A | HYPOTENSIVE, ANTIISCHEMIC AGENTS | DR. KARL THOMAE GMBH | 1989-10-03 | — | — | US | disclosed |
| EP-0259793-A1 | Naphthyl derivatives, medicaments containing them and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-03-16 | — | — | EP | disclosed |