Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.52 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 6/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10873013 | 0.93 | HPGD (0.52) | CA12CA1CA2CA7CA13 | |
| SCHEMBL11101907 | 0.91 | HPGD (0.49) | CA12CA1CA2CA7CA13 | |
| SCHEMBL22960673 | 0.88 | RAB9A (0.51) | CA12CA1CA2CA7CA13 | |
| SCHEMBL15526640 | 0.88 | CA12 (0.52) | CA12CA1CA2CA7CA13 | |
| SCHEMBL9338307 | 0.86 | HPGD (0.57) | CA12CA1CA2CA7CA13 | |
| SCHEMBL1017821 | 0.86 | HTT (0.51) | CA12CA1CA2CA7CA13 | |
| SCHEMBL31500032 | 0.85 | THRB (0.64) | THRATHRBMAOAMAOBPTGS2 | |
| SCHEMBL11349193 | 0.82 | PLK1 (0.53) | THRATHRBALDH1A1PTGS2HPGD | |
| SCHEMBL13397872 | 0.82 | CA12 (0.61) | CA12CA1CA2CA7CA13 | |
| SCHEMBL10870758 | 0.81 | HPGD (0.68) | CA12CA1CA2CA7CA13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0508999-A1 | PHARMACEUTICALLY ACTIVE NORMONYL COMPOUNDS | Beecham Group p.l.c. (GB) | 1992-10-21 | — | — | EP | claimed |
| EP-0508999-A1 | PHARMACEUTICALLY ACTIVE NORMONYL COMPOUNDS | Beecham Group p.l.c. (GB) | 1992-10-21 | — | — | EP | disclosed |
| WO-1991009855-A1 | PHARMACEUTICALLY ACTIVE NORMONYL COMPOUNDS | BEECHAM GROUP PLC (GB) | 1991-07-11 | — | — | WO | disclosed |