Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 17/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.49 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.49 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.49 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9667471 | 0.86 | PTAFR (0.72) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL10464240 | 0.85 | PTAFR (0.65) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL9668068 | 0.84 | PTAFR (0.71) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL9669277 | 0.84 | PTAFR (0.62) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL9670207 | 0.83 | PTAFR (0.70) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL9669241 | 0.83 | PTAFR (0.56) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL9668954 | 0.81 | PTAFR (0.74) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL9667557 | 0.80 | PTAFR (0.49) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL11512288 | 0.77 | PTAFR (0.64) | PTAFROPRK1PDE4DGABRA1GABRA5 | |
| SCHEMBL8878047 | 0.73 | PTAFR (0.60) | PTAFRCYP3A4ALOX15OPRK1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230942-B1 | THIENO-1,4-DIAZEPINES | BOEHRINGER INGELHEIM KG (DE) | 1992-04-29 | — | — | EP | disclosed |
| EP-0230942-A2 | Thieno-1,4-diazepines | BOEHRINGER INGELHEIM KG (DE) | 1987-08-05 | — | — | EP | disclosed |