Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9669212 | 0.89 | PDE3B (0.44) | CYP19A1PDE3BPDE3ACDC7CDK5 | |
| SCHEMBL9670085 | 0.83 | PDE3A (0.40) | CYP19A1PDE3BPDE3ACDK5 | |
| SCHEMBL9668036 | 0.82 | CTSV (0.41) | KDM4ERAB9AMAPTMEN1KMT2A | |
| SCHEMBL9668854 | 0.82 | PDE3A (0.43) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL9669202 | 0.79 | PDE3A (0.36) | KDM4ENPC1RAB9ASMN1; SMN2PDE3B | |
| SCHEMBL7380645 | 0.78 | PDE3A (0.54) | MEN1KMT2AALDH1A1SMN1; SMN2PDE3B | |
| SCHEMBL9669040 | 0.71 | SMN1; SMN2 (0.60) | CYP19A1KDM4ENPC1RAB9AMAPT | |
| SCHEMBL2847471 | 0.70 | PDE3A (0.44) | PDE3BPDE3ACYP2C9 | |
| SCHEMBL5183107 | 0.70 | PDE3A (0.44) | MEN1PDE3BPDE3AMAP4K4MKNK2 | |
| SCHEMBL11075203 | 0.69 | NPC1 (0.53) | KDM4ENPC1RAB9AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0223937-B1 | INDOLES SUBSTITUTED WITH HETEROCYCLES, INTERMEDIATES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS | Roche Diagnostics GmbH (DE) | 1992-03-18 | — | — | EP | disclosed |
| US-4851406-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE | BOEHRINGER MANNHEIM GMBH (DE) | 1989-07-25 | — | — | US | disclosed |