Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9850874 | 0.86 | TP53 (0.70) | TP53TSHRHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL9670440 | 0.85 | TP53 (0.54) | TP53TSHRHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL2957434 | 0.83 | HPGD (0.53) | TP53TSHRHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL19559566 | 0.82 | SMN1; SMN2 (0.60) | TP53TSHRHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL10405140 | 0.81 | SMN1; SMN2 (0.53) | TP53TSHRHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL10404767 | 0.80 | SMN1; SMN2 (0.47) | TP53TSHRHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL9669910 | 0.79 | KDM1A (0.47) | TP53TSHRHPGDLMNASRD5A1 | |
| SCHEMBL9668039 | 0.79 | TP53 (0.44) | TP53TSHRHPGDSMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9669646 | 0.79 | KDM1A (0.46) | TP53TSHRHPGDLMNASRD5A1 | |
| SCHEMBL9667995 | 0.78 | MEN1 (0.46) | TP53TSHRHPGDSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0236263-B1 | SUBSTITUTED PYRROLIDINONES | CIBA-GEIGY AG (CH) | 1992-12-30 | — | — | EP | disclosed |
| US-4945092-A | Substituted 1-(oxopyrrolidinylalkanoyl)-piperazines useful as nootropics | CIBA-GEIGY CORPORATION (US) | 1990-07-31 | — | — | US | disclosed |
| EP-0236263-A2 | Substituted pyrrolidinones | CIBA-GEIGY AG (CH) | 1987-09-09 | — | — | EP | disclosed |