Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.55 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.55 |
| ▸ | BRD4 | O60885 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1906215 | 0.88 | TP53 (0.67) | TP53HPGDTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL563022 | 0.88 | TP53 (0.67) | TP53HPGDTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL3155232 | 0.88 | TP53 (0.67) | TP53HPGDTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL9670440 | 0.86 | TP53 (0.54) | TP53HPGDTSHRALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL32688148 | 0.86 | TP53 (0.65) | TP53HPGDTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL9669356 | 0.86 | TP53 (0.54) | TP53HPGDTSHRALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL32688158 | 0.86 | TP53 (0.65) | TP53HPGDTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL11553488 | 0.84 | LMNA (0.71) | TP53HPGDTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL20573309 | 0.84 | TP53 (0.74) | TP53HPGDTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL32688308 | 0.84 | TP53 (0.74) | TP53HPGDTSHRALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4144246-A | COGNITION ACTIVATORS | PARKE, DAVIS & COMPANY (US) | 1979-03-13 | — | — | US | claimed |
| US-8338622-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-12-25 | — | — | US | disclosed |
| US-8338622-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-12-25 | — | — | US | disclosed |
| US-20110251187-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-10-13 | — | — | US | disclosed |
| US-20110251187-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-10-13 | — | — | US | disclosed |
| EP-2295406-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-03-16 | — | — | EP | disclosed |
| EP-0440789-A1 | CARBALKOXYMETHYL ETHERS OF LACTAM-1-ACETIC ACID AND METHOD OF OBTAINING THEM | 2-i MOSKOVSKY GOSUDARSTVENNY MEDITSINSKY INSTITUT IMENI N.I. PIROGOVA (SU) | 1991-08-14 | — | — | EP | disclosed |
| US-4144246-A | COGNITION ACTIVATORS | PARKE, DAVIS & COMPANY (US) | 1979-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251187-A1 | HETEROCYCLIC COMPOUND | NES, BMI1, DOT1L | TP53 564/4885HPGD 1800/4885TSHR 4026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.