Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | FER | P16591 | 1/20 | 0.52 |
| ▸ | LTK | P29376 | 1/20 | 0.52 |
| ▸ | CDK8 | P49336 | 1/20 | 0.52 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.52 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20087021 | 0.80 | ALDH1A1 (0.41) | LRRK2PDGFRAFERLTKCDK8 | |
| SCHEMBL16385898 | 0.78 | LRRK2 (0.52) | LRRK2PDGFRAFERLTKCDK8 | |
| SCHEMBL7513257 | 0.78 | LRRK2 (0.52) | LRRK2PDGFRAFERLTKCDK8 | |
| SCHEMBL1462143 | 0.76 | IDO1 (0.55) | GSK3BL3MBTL1ALDH1A1KDM4EIDO1 | |
| SCHEMBL31728760 | 0.76 | IDO1 (0.55) | GSK3BL3MBTL1ALDH1A1KDM4EIDO1 | |
| SCHEMBL8120629 | 0.76 | LRRK2 (0.46) | LRRK2PDGFRAFERLTKCDK8 | |
| SCHEMBL10444510 | 0.74 | LRRK2 (0.47) | LRRK2PDGFRAFERLTKCDK8 | |
| SCHEMBL8136999 | 0.74 | ALDH1A1 (0.47) | LRRK2PDGFRAFERLTKCDK8 | |
| SCHEMBL6904734 | 0.73 | MEN1 (0.52) | MAOASMN1; SMN2KDM4EIDO1MAPT | |
| SCHEMBL366728 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273401-B1 | ISOINDOLIN-1-ONE DERIVATIVE AND ANTIARRHYTHMIC AGENT | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1992-11-11 | — | — | EP | disclosed |
| US-4849441-A | Isoindolin-1-one derivative and antiarrhythmic agent | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-07-18 | — | — | US | disclosed |
| EP-0273401-A1 | Isoindolin-1-one derivative and antiarrhythmic agent | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1988-07-06 | — | — | EP | disclosed |