Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9670156 | 0.93 | BCHE (0.48) | BCHEACHEPDGFRBKDRFGFR1 | |
| SCHEMBL9669351 | 0.92 | BCHE (0.47) | BCHEACHEPDGFRBKDRFGFR1 | |
| SCHEMBL9669472 | 0.88 | CHEK1 (0.41) | BCHEACHEPDGFRBKDRFGFR1 | |
| SCHEMBL10481169 | 0.83 | BCHE (0.40) | BCHEACHEPDGFRBKDRFGFR1 | |
| SCHEMBL9669370 | 0.82 | BCHE (0.47) | BCHEACHEALDH1A1CHRM2PDGFRA | |
| SCHEMBL10481158 | 0.80 | BCHE (0.36) | BCHEACHEPDGFRBKDRFGFR1 | |
| SCHEMBL9669489 | 0.79 | BCHE (0.59) | BCHEACHEALDH1A1HPGDCHRM2 | |
| SCHEMBL12354492 | 0.67 | BCHE (0.61) | BCHEACHEALDH1A1MEN1KMT2A | |
| SCHEMBL16385898 | 0.67 | LRRK2 (0.52) | ALDH1A1HPGDKDM4EPDGFRAFER | |
| Phthalimide SCHEMBL1581683 | 0.66 | GSK3B (0.65) | MEN1GAAGFERKMT2APDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273401-B1 | ISOINDOLIN-1-ONE DERIVATIVE AND ANTIARRHYTHMIC AGENT | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1992-11-11 | — | — | EP | disclosed |
| US-4849441-A | Isoindolin-1-one derivative and antiarrhythmic agent | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-07-18 | — | — | US | disclosed |
| EP-0273401-A1 | Isoindolin-1-one derivative and antiarrhythmic agent | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1988-07-06 | — | — | EP | disclosed |