Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.59 |
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | FER | P16591 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9670156 | 0.82 | BCHE (0.48) | BCHEACHEKDM4EALDH1A1HSD17B10 | |
| SCHEMBL9669370 | 0.81 | BCHE (0.47) | BCHEACHEALDH1A1SMN1; SMN2PDGFRA | |
| SCHEMBL9669351 | 0.81 | BCHE (0.47) | BCHEACHEKDM4EALDH1A1HSD17B10 | |
| SCHEMBL9669494 | 0.79 | BCHE (0.43) | BCHEACHEKDM4EALDH1A1MEN1 | |
| SCHEMBL22184064 | 0.77 | ACHE (1.00) | BCHEACHEKDM4EALDH1A1MEN1 | |
| SCHEMBL10338752 | 0.75 | KDM4E (0.57) | BCHEACHEKDM4EALDH1A1HSD17B10 | |
| SCHEMBL3259666 | 0.72 | BCHE (0.89) | BCHEACHEMEN1KMT2A | |
| SCHEMBL28859790 | 0.68 | SIGMAR1 (0.55) | KDM4EALDH1A1HSD17B10KMT2ASMN1; SMN2 | |
| SCHEMBL9669472 | 0.68 | CHEK1 (0.41) | BCHEACHEKDM4EALDH1A1MEN1 | |
| SCHEMBL12281008 | 0.67 | ACHE (0.79) | BCHEACHEMEN1KMT2ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273401-B1 | ISOINDOLIN-1-ONE DERIVATIVE AND ANTIARRHYTHMIC AGENT | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1992-11-11 | — | — | EP | disclosed |
| US-4849441-A | Isoindolin-1-one derivative and antiarrhythmic agent | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-07-18 | — | — | US | disclosed |
| EP-0273401-A1 | Isoindolin-1-one derivative and antiarrhythmic agent | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1988-07-06 | — | — | EP | disclosed |