Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.40 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 9/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | CHRNA10 | Q9GZZ6 | 3/20 | 0.36 |
| ▸ | CHRNA9 | Q9UGM1 | 3/20 | 0.36 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9670776 | 0.86 | KCNH2 (0.55) | KCNH2CHRNA7CHRNB4CHRNA3CHRM2 | |
| Iodide SCHEMBL9670708 | 0.80 | CHRM2 (0.59) | SIGMAR1CHRM2CHRM1CHRM3CYP1A2 | |
| Iodide SCHEMBL9670592 | 0.80 | KCNH2 (0.50) | KCNH2CHRNA7CHRNB4CHRNA3CHRNB2 | |
| Iodide SCHEMBL9671893 | 0.79 | KCNH2 (0.62) | KCNH2CHRNA7CHRNB4CHRNA3CHRM2 | |
| Iodide SCHEMBL9671951 | 0.78 | KCNH2 (0.66) | KCNH2CHRNA7CHRNB4CHRNA3CHRM2 | |
| Iodide SCHEMBL9671839 | 0.78 | KCNH2 (0.66) | KCNH2CHRNA7CHRNB4CHRNA3CHRM2 | |
| Iodide SCHEMBL9672169 | 0.78 | KCNH2 (0.66) | KCNH2CHRNA7CHRNB4CHRNA3CHRM2 | |
| Iodide SCHEMBL9671227 | 0.78 | KCNH2 (0.66) | KCNH2CHRNA7CHRNB4CHRNA3CHRM2 | |
| SCHEMBL1537772 | 0.74 | SKP2 (0.55) | SIGMAR1CHRM2CHRM1CHRM3CYP1A2 | |
| SCHEMBL31593167 | 0.74 | SKP2 (0.55) | SIGMAR1CHRM2CHRM1CHRM3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5093370-A | Useful prior to insertion of tracheotomy tube or discission | TOBISHI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 1992-03-03 | — | — | US | disclosed |