Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | RARB | P10826 | 6/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RARA | P10276 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.37 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9670776 | 0.94 | KCNH2 (0.55) | KCNH2CHRNA7CHRNB4CHRNA3CHRNB2 | |
| Iodide SCHEMBL9671893 | 0.87 | KCNH2 (0.62) | KCNH2CHRNA7CHRNB4CHRNA3HSD17B10 | |
| Iodide SCHEMBL9671839 | 0.85 | KCNH2 (0.66) | KCNH2CHRNA7CHRNB4CHRNA3HSD17B10 | |
| Iodide SCHEMBL9672169 | 0.85 | KCNH2 (0.66) | KCNH2CHRNA7CHRNB4CHRNA3HSD17B10 | |
| Iodide SCHEMBL9671227 | 0.85 | KCNH2 (0.66) | KCNH2CHRNA7CHRNB4CHRNA3HSD17B10 | |
| Iodide SCHEMBL9671951 | 0.85 | KCNH2 (0.66) | KCNH2CHRNA7CHRNB4CHRNA3HSD17B10 | |
| Hydrochloric Acid SCHEMBL9672440 | 0.81 | KCNH2 (0.66) | KCNH2CHRNA7CHRNB4CHRNA3HSD17B10 | |
| SCHEMBL17363942 | 0.81 | CHRNB4 (0.54) | KCNH2CHRNA7CHRNB4CHRNA3CHRNB2 | |
| Iodide SCHEMBL9670489 | 0.80 | KCNH2 (0.44) | KCNH2CHRNA7CHRNB4CHRNA3CHRNB2 | |
| Hydrochloric Acid SCHEMBL2154841 | 0.79 | CHRNB4 (0.53) | KCNH2CHRNA7CHRNB4CHRNA3CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5093370-A | Useful prior to insertion of tracheotomy tube or discission | TOBISHI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 1992-03-03 | — | — | US | disclosed |