Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 5/20 | 0.59 |
| ▸ | CHRM3 known ✓ | P20309 | 5/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9670543 | 0.84 | ALDH1A1 (0.58) | CHRM2CHRM1CHRM3SIGMAR1ALDH1A1 | |
| Iodide SCHEMBL9670489 | 0.80 | KCNH2 (0.44) | CHRM2CHRM1CHRM3SIGMAR1CYP1A2 | |
| Iodide SCHEMBL9671520 | 0.78 | ALDH1A1 (0.52) | CHRM2CHRM1CHRM3ALDH1A1PKM | |
| Iodide SCHEMBL9677423 | 0.78 | ALDH1A1 (0.56) | CHRM2CHRM1CHRM3ALDH1A1PKM | |
| Iodide SCHEMBL9671924 | 0.76 | ALDH1A1 (0.54) | CHRM2CHRM1CHRM3ALDH1A1PKM | |
| Iodide SCHEMBL9670702 | 0.76 | ALDH1A1 (0.54) | CHRM2CHRM1CHRM3ALDH1A1PKM | |
| Iodide SCHEMBL9671942 | 0.75 | CHRM2 (0.64) | CHRM2CHRM1CHRM3ALDH1A1PKM | |
| Iodide SCHEMBL28875132 | 0.74 | CHRM2 (0.58) | CHRM2CHRM1CHRM3SIGMAR1ALDH1A1 | |
| SCHEMBL1537772 | 0.73 | SKP2 (0.55) | CHRM2CHRM1CHRM3SIGMAR1ALDH1A1 | |
| SCHEMBL31593167 | 0.73 | SKP2 (0.55) | CHRM2CHRM1CHRM3SIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5093370-A | Useful prior to insertion of tracheotomy tube or discission | TOBISHI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 1992-03-03 | — | — | US | disclosed |